Scientists Expand The Lifespan Of A Worm By 500 Percent – The Equivalent Of 400 Years In Humans - Physics-Astronomy.org

Scientists Expand The Lifespan Of A Worm By 500 Percent – The Equivalent Of 400 Years In Humans

At first glance, Caenorhabditis elegans may not appear to have much in common with people. The microscopic nematode grows to just about 1 millimeter in length and thrives in soil environments – especially rotting vegetation. But behind the genetic scenes, this tiny worm may help scientists combat one of humanity’s greatest challenges: aging.




A team of researchers from MDI Biological LaboratoryBuck Institute for Research on Aging California, and China’s Nanjing University studying C. elegans has identified two cellular pathways found in the worm that govern aging. When altered, IIS and TOR can expand the lifespan of the animal by 500 percent – the equivalent of a person living for up to 500 years. Oddly enough, both IIS and TOR are also present in people.


IFLScience spoke with study authors Jarod Rollins and Aric Rogers, who responded jointly to interview questions. They explain that IIS reacts to environmental factors, like food, to coordinate an organism’s cellular response among different tissues. It is responsible for signaling insulin that, when targeted by CRISPR and subsequently mutated, increases the lifespan of C. elegans by 100 percent. On the other hand, TOR is a nutrient sensor that lives within cells that responds to changes in food availability even more ancient than hormone signaling, which the researchers note became necessary during the evolution of single-cell to multicellular species. When manipulated, TOR results in a 30 percent increase in longevity.

Roundworms share many genes with humans and also have a short lifespan of between three and four weeks, allowing scientists to study long-term effects in a truncated timespan. MDI Biological Laboratory

“Together, lowering activity of IIS and TOR are thought to influence aging by switching cells from a growth model to one that favors maintenance,” explained the researchers, adding that this “wild” effect isn’t a “one plus one equals two, its one plus one equals five” but results in the amplification of the worm’s month-long lifespan by 500 percent – an extension greater than the sum of the two separate mutations, a concept known as a “synergistic effect.”


“Many of the same genes and genetic pathways are shared between nematodes and humans. Tweaking activity of similar genes in humans with drugs or other therapeutics, while unlikely to cause a 500 percent lifespan extension, may produce a similar kind of synergistic reaction when both gene pathways are targeted simultaneously,” explained Rollins and Rogers.
It is believed that longevity is regulated in mitochondria, organelles responsible for cell energy, and builds on a body of evidence that suggests mitochondria dysregulation is linked to aging. The findings could help to explain why researchers have not identified a single longevity gene responsible for helping some people to live to extraordinarily old ages free of age-related diseases until just before death. It could also one day lead to combination therapies that work together to target individually different pathways to extend healthy human life.
The real question: Might humans one day expect to live for five centuries?
“It’s is certainly possible, there are lots of examples in nature of organisms that live a very long time. However, the real focus of the field is to enable humans to live as healthy as possible for as long as possible by preventing age-related decline in health,” said the researchers.
The team notes that the scientific community is on the precipice of exciting changes in medical approaches, but admit that seeing these changes put in place is a bit like “pulling teeth”.
“People are suffering and medical costs are skyrocketing. It’s time for all of us to get serious about incorporating broad scope preventative medical approaches to lessen the prevalence and severity of age-related diseases,” they added.


The findings are published in Cell Reports.

Creating transgenic, or genetically altered, animals is now much more rapid, routine, and precise with the use of CRISPR technology for studying the effects of aging. MDI Biological Laboratory

5 comments:

  1. Hello everyone i Am williams pater and i am from USA i am here to give my testimony about an herbal doctor called Dr,olu I was heartbroken because i had very small penis,not nice to satisfy a woman, i have been in so many relationship, but cut off because of my situation, i have used so many product which doctors prescribe for me, but could not offer me the help i searched for. i saw some few comments on the internet about this specialist called Dr,OLU and decided to email him on his email i saw on the internet,(drolusolutionhome@gmail.com ) so I decided to give his herbal product a try. i emailed him and he got back to me, he gave me some comforting words with his herbal product for Penis Enlargement, Within three weeks of me use it, i began to feel the enlargement, " and now it just 4 weeks of using his products my penis is about 8 inches longer, and i had to settle thing out with my ex girlfriend , i was surprised when she said that she is satisfied with my performance in bed and i now have a large penis.thanks to DR OLU for is herbal product. you can also reach him with emsil  drolusolutionhome@gmail.com though is..number WHATASPP him today on this number [ +2348140654426 ] 

    ReplyDelete
    Replies

    1. I have been suffering from HIV and Genital Herpes for the past 3 years and 8 months, and ever since then i have been taking series of treatment but there was no improvement until i came across testimonies of Dr TAKUTA on how he has been curing different people from different diseases all over the world, then i contacted him as well. After our conversation he sent me the medicine which i took according to his instructions. When i was done taking the herbal medicine i went for a medical checkup and to my greatest surprise i was cured from Herpes. My heart is so filled with joy. If you are suffering from Herpes or any other disease you can contact Dr TAKUTA today on this Email address: takutaspellalter@gmail.com or WhatsApp him on this Tell.Number +27788634102....

      Dr.TAKUTA also cures:
      1. HEPATITIS A,B,C
      2. HERPES 1/2
      3.DIABETES
      4.STROKE.
      5.STDS and STI
      6. MARRIAGE COUNSELLING
      7.LOVE SPELL CASTING
      8.JOB PROMOTION SPELLS
      9.MARITAL PROBLEM
      10.MAGIC MONEY SPELLS



















      I have been suffering from HIV and Genital Herpes for the past 3 years and 8 months, and ever since then i have been taking series of treatment but there was no improvement until i came across testimonies of Dr TAKUTA on how he has been curing different people from different diseases all over the world, then i contacted him as well. After our conversation he sent me the medicine which i took according to his instructions. When i was done taking the herbal medicine i went for a medical checkup and to my greatest surprise i was cured from Herpes. My heart is so filled with joy. If you are suffering from Herpes or any other disease you can contact Dr TAKUTA today on this Email address: takutaspellalter@gmail.com or WhatsApp him on this Tell.Number +27788634102....

      Dr.TAKUTA also cures:
      1. HEPATITIS A,B,C
      2. HERPES 1/2
      3.DIABETES
      4.STROKE.
      5.STDS and STI
      6. MARRIAGE COUNSELLING
      7.LOVE SPELL CASTING
      8.JOB PROMOTION SPELLS
      9.MARITAL PROBLEM
      10.MAGIC MONEY SPELLS



























      I have been suffering from HIV and Genital Herpes for the past 3 years and 8 months, and ever since then i have been taking series of treatment but there was no improvement until i came across testimonies of Dr TAKUTA on how he has been curing different people from different diseases all over the world, then i contacted him as well. After our conversation he sent me the medicine which i took according to his instructions. When i was done taking the herbal medicine i went for a medical checkup and to my greatest surprise i was cured from Herpes. My heart is so filled with joy. If you are suffering from Herpes or any other disease you can contact Dr TAKUTA today on this Email address: takutaspellalter@gmail.com or WhatsApp him on this Tell.Number +27788634102....

      Dr.TAKUTA also cures:
      1. HEPATITIS A,B,C
      2. HERPES 1/2
      3.DIABETES
      4.STROKE.
      5.STDS and STI
      6. MARRIAGE COUNSELLING
      7.LOVE SPELL CASTING
      8.JOB PROMOTION SPELLS
      9.MARITAL PROBLEM
      10.MAGIC MONEY SPELLS










































      Delete
  2. Mon témoignage sur la façon dont j'ai été guérie du virus de l'herpès
    J'ai été une fois victime du virus de l'herpès avec de nombreuses épidémies sur mon corps, j'ai été guérie du virus grâce à l'aide du docteur Ahmed Usman en phytothérapie. J'ai rencontré la plupart de ses témoignages de patients sur des blogs et des pages de réseaux sociaux, guéri de diverses maladies. Je l'ai contacté avec son adresse e-mail à laquelle il a répondu et m'a posé quelques questions et la méthode de préparation pour laquelle j'ai payé, il m'a envoyé des plantes médicinales et avec sa prescription j'ai bu des herbes médicinales pendant 21 jours et les épidémies sur mon corps ont été guéries après avoir conclu la phytothérapie, je suis allé pour le test et mon résultat était négatif sans trace de virus sur mon sang. Vous pouvez également être guéri, contactez-le sur son email officiel; drahmedusman5104@gmail.com.
    Il a dit qu'il avait un remède à base de plantes pour
    le diabète, le cancer, les fibromes, l'hyperglycémie, l'hépatite,
    le VIH, les maladies cardiaques et les maladies du foie.

    ReplyDelete
  3. My Name is Dr sebi you can Contact Me via Email drsebicurecenter@gmail.com For Penis Enlargement Product to help you get as long as 8inches Long with good Erection. Contact Me Via Email : drsebicurecenter@gmail.com   Via WhatsApp +2347010538590

    ReplyDelete
  4. Hi everybody. I recently saw a testimony about chief dr lucky in a blog I visit for relationship and dating counseling problems because i had been having serious issues with my boyfriend and we had been dating for six months, he just suddenly changed, he wasn't returning my calls,he started cheating,he was hurting me in many ways i never thought possible and I just thought I should try it*maybe out of desperation of some sort*..and I contacted chief dr lucky ..At first everything felt dreamy and unbelievable, his consultations and solution was a little bit easy and strange and I was scared a little cause I heard read and heard lots of stories to of fake spell casters,scams and i never really believed in magic..I played along with a little hope and and faith and I sent some few stuffs after everything and it worked like a miracle,everything went to a while new direction,it was and is amazing...I guess it was all good faith that made me read That particular post that faithful day..I hope he could help other people too like he did me...I did a little and I got everything I wanted and wished for*my husband,my family and my life back. E-mail: Cheifdrlucky@gmail.com or contact him on whats App him +2348132777335 Website :http://chiefdrluckysolutionhome.website2.me/  

    ReplyDelete

Powered by Blogger.