Spraying Stem Cells Up The Noses of Mice Has Restored Their Sense of Smell - Physics-Astronomy.org

Spraying Stem Cells Up The Noses of Mice Has Restored Their Sense of Smell

Imagine a simple and effective treatment for restoring the sense of smell in people who have lost it or never had it in the first place – that could one day be possible as a result of early stage research on mice, in which olfactory nerves were replenished using stem cells.
Using droplets of globose basal cells – the same cells that naturally replace damaged and ageing neurons related to smell – scientists were able to get them to develop into full nerve cells, stretching right into the brain.


Ultimately a few squirts of stem cells were able to reconnect the axonsleading to the olfactory signalling in the brains of the mice. Scientists are still a long way from repeating the trick with human beings, but it's a very promising start.


"This is the first model of smell loss showing evidence of recovery using a cell-based therapy," says lead researcher and otolaryngologist Bradley Goldstein, from the University of Miami.
"It is very important to understand that many questions would need to be worked out before considering this in a human patient. However, it does provide evidence that such an approach warrants further study."
Goldstein and his colleagues worked with mice that had been genetically modified to lose their sense of smell – in particular, the absence of the IFT88 gene meant the mice cells lacked cilia, the tiny hair-like structures that detect scents and odours.
After the globose basal cells were applied, and developed into fully mature olfactory sensory neurons inside the olfactory epithelium (the nasal cavity), the treated mice started reacting to bad smells.


"There is some evidence that a failure to normally replace damaged or lost olfactory neurons may contribute to many forms of acquired olfactory loss," says Goldstein. "So, we were interested in testing the idea that a cell-based therapy approach, to replace neurons, might be plausible."
"We were a bit surprised to find that cells could engraft fairly robustly with a simple nose drop delivery."
In the US, 12 percent of the population have problems with their sense of smell, due to ageing, a genetic disorder, or some kind of injury. That's almost 40 million people, and right now there aren't a lot of treatments available.
With many of those issues seemingly linked to the olfactory epithelium and its tissue lining, this stem cell approach might work – though adapting the approach to see if it is as effective in human beings is going to take time. Scientists will also need to make sure there aren't any adverse side effects.
A healthy sense of smell not only enriches life – when walking through a garden or a kitchen perhaps – it can also act as a useful warning system for everything from out-of-date food to a gas leak.
"To be potentially useful in humans, the main hurdle would be to identify a source of cells capable of engrafting, differentiating into olfactory neurons, and properly connecting to the olfactory bulbs of the brain," says Goldstein.
"Further, one would need to define what clinical situations might be appropriate, rather than the animal model of acute olfactory injury."

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    ReplyDelete
  13. Happiness is all i see now I never thought that I will be cured from HERPES virus again. I have been suffering from a deadly disease (HERPES) for the past 3 years now, I had spent a lot of money going from one places to another, from churches to churches, hospitals have been my home every day residence. Constant checks up have been my hobby not until this faithful day, I was searching through the internet, I saw a testimony on how DR Ohunyom helped someone in curing his HERPES disease, quickly I copied his email which is
    drohunyom@gmail.com just to give him a try I spoke to him, he asked me to do some certain things which I did, he told me that he is going to provide the herbal cure to me, which he did, then he asked me to go for medical checkup after some days after using the herbal cure, behold I was free from the deadly disease, he only asked me to post the testimony through the whole world, faithfully am doing it now, please brothers and sisters, he is great, I owe him in return. if you are having a similar problem just email him on (drohunyom@gmail.com) or you can whatsApp him +2349060579973 and He also has herbal cure for the Following DISEASES, eczema,urethra wart,chronic problems.Herpes, Cancer, Als,Hepatitis, Diabetes, HPV,Infections,ulcer ETC

    ReplyDelete
  14. NATURAL HERBS FOR CURING HIV, HERPES, HPV, HSV1&2, CANCER AND DIABETES

    I just experience the wonders of Dr Ohunyom herbs. God will continue to bless you Dr Ohunyom more abundantly for the good work you are doing in peoples life by curing them from different type of diseases. I will keep on testifying about your good work. I was diagnosed of herpes 6 months ago and my doctor told me that there is no cure. I did not believe him and i keep my faith up hoping that one day i will be cured from this horrible disease. One day i saw a post on HIV forum about a herbal doctor called Dr Ohunyom on how he cure people from diseases with his herbs and i quickly contact Dr Ohunyom on his email and explain my problem to him and he told me not to worry that he is going to cure me and truly he prepared the cure and send it to me through UPS and gave me instructions on how to take it. After two weeks of taken the herbal cure, i went to my doctor for checkup and my result show Negative and my doctor told me that there is no trace of herpes in my body and the virus is completely gone from my body. Everybody at the clinic rejoice with me and they all ask for Dr Ohunyom contact. You can contact Dr Ohunyom on his email: drohunyom@gmail.com or WhatsApp him on +2349060579973.and He also have herbs medicine to cured the following diseases; eczema,urethra wart,chronic problems.Herpes, Cancer, Als,Hepatitis, Diabetes, HPV,Infections,ulcer  ETC

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  15. Life has not been easy for me, I am here to share the good news of my life, how I was cure through HSV2 by doc Aziegbe who help me within 2 weeks with the help of his herbal medicine I am from United states of America, so this Great doctor sent me a herbal which I took according to the way he instructed, just to find out I am cure after taking the cure for 2 week I found this man email from the internet, how he also help a lady from the same sickness. I am so happy to be writing this testimony to the world because this man really clean the tears in my heart and he is a man of his words I want to use this means to inform those of us who’s doctor had told there is no cure, well here is the chance to get yourself cured from this horrible sickness you can get Dr Aziegbe email here DRAZIEGBE1SPELLHOME@GMAIL. COM or you can also whatapp him +2349035465208 and the doctor also told me he can fix this sickenss also: 1. HIV / AIDS 2. HPV 3. CANCER 4. ALS (Lou Gehrig’s disease) 5. Hepatitis B

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  16. I'm so exited to share my testimonies about the Good Work of Dr. Emmanuel who cured my Herpes virus with his herbs, I never thought that I will live on earth before the year runs out. I have been suffering from a deadly Herpes virus (HVS) for the past (4)years now; I had spent a lot of money going from one Hospital to another looking for way to get rid of this disease, the hospital have been my home everyday residence. Constant checks up have been my hobby not until this faithful day, I was searching
    through the internet, I saw a testimony on how Dr.Emmanuel helped someone in curing his Herpes virus using his healing
    Herbs, quickly I copied his email just to give him a test I spoke to him, he asked me to a preparation for the herbs items, of which I did exactly what he instructed me to do, he told me that he is going to provide the herbal cure to me, which he
    did, few days after i went back to the same hospital that previously confirmed me as Herpes virus positive and this time the result declared me negative to the deadly virus of Herpes virus....so I decided to share my testimony, that nothing is impossible with God, God use a man to healed me. No matter what you are passing through, no matter how deadly the sickness is and no matter what the situation is God that did mine is still going to do yours, suffering from AIDS, ALS,hiv/aids,copd, asthma.. Cancer,Hpv, any kind of disease, you can rich him now via ? Gmail address: ( nativehealthclinic@gmail.com) or WhatsApp number +2348140073965,doctor Emmanuel IG: @dremmanuel2

    thank you.

    ReplyDelete
  17. I want to write a little testimony about the good work of doctor KUTA who cured me from Hsv 1 and 2 for just 2 week with his herbal medicine, I never believe I can be normal again and have a good life like others I always regretted the day I got diagnose with the virus, I was lost of hope when my doctor told me there is no cure for it but I keep thinking and thinking about my future, if I can have kids of my own well I am so grateful for my helper who get me cured with his herbal medicine, I go online in search of anything that can help me because I can’t deal with it forever so I found this doc KUTA email on a blog of someone who was cured by him I quickly contact him for help and explain all my pain to him, he told me not to worry about it there is cure for real, I never believe until he send me the herbal medicine when I order for it and I have it within 4 days that is how I took the medicine for 2 week and the following week I go for test just to confirm I was 100% cured from this sickness what a miracle in my life I am so happy right now, you can also get in contact with him if you have such sickness through drkutaherbalcenter@gmail.com and also WhatsApp him +2347054547814... And He also have herbs medicine to cured the following diseases; eczema,urethra wart,chronic problems.Herpes, Cancer, Als,Hepatitis, Diabetes, HPV,Infections,ulcer ETC

    ReplyDelete
  18. CURED FROM   Human Papillomavirus    (  HPV)
     Most grateful to DR HASSAN for changing my life by destroying the yoke of Human Papillomavirus    from my body system with herbal roots and herbs. I have lived with HPV for 5 years now, I started using supplements  until  a friend on Facebook shared his testimony of a herbal DR specialize on curing Human Papillomavirus  and HSV ! everyone on the site were talking about him so i got connected to the herbal DR ,he assured me i will get rid of the virus within a 21 days. I believed and had faith in him for i really needed his help. He sent me the herbal medication through UPS delivery service.I used the medication for 21 days, I was experiencing changes in my body because there were no genital warts that appear like  small bump, cluster of bumps, or stem-like protrusions  were gone and now i have gotten myself back through herbal means and i was confirmed negative to this virus by my doctor.I advice you do the same by contacting this herbal DR  Email:(drhassanherbscure@gmail.com)  call him/WhatsApp  ( +2349032582239 )

    ReplyDelete
  19. HOW I GOT MY LOAN FROM THIS GREAT COMPANY

    Hello my dear people, I am Linda McDonald, currently living in Austin Texas, USA. I am a widow at the moment with three kids and i was stuck in a financial situation in April 2018 and i needed to refinance and pay my bills. I tried seeking loans from various loan firms both private and corporate but never with success, and most banks declined my credit ,do not full prey to those hoodlums at there that call them self-money lender they are all scam , all they want is your money and you well not hear from them again they have done it to me twice before I met Mr. David Wilson the most interesting part of it is that my loan was transfer to me within 74hours so I will advise you to contact Mr. David if you are interested in getting loan and you are sure you can pay him back on time you can contact him via email……… (davidwilsonloancompany4@gmail.com) No credit check, no cosigner with just 2% interest rate and better repayment plans and schedule if you must contact any firm with reference to securing a loan without collateral then contact Mr. David Wilson today for your loan

    They offer all kind of categories of loan they

    Short term loan (5_10years)
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    They offer loan like
    Home loan............., Business loan........ Debt loan.......
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    Email..........( davidwilsonloancompany4@gmail.com)
    When it comes to financial crisis and loan then David Wilson loan financial is the place to go please just tell him I Mrs. Linda McDonald direct you Good Luck.......................

    ReplyDelete
  20. I Can't still believe that i got cured from Genital Herpes through herbal treatment from Dr Aire who I met through the internet, I actually couldn't believe it at first because it sounded impossible to me knowing how far I have gone just to get rid of it. Dr Aire send me his medicine ich I took as instructed and here I am living a happy life once again, a big thanks to Dr Aire, I am sure there are many herbal doctors out there but Dr Aire did it for me, contact him drairehome@gmail.com , also call or whatsApp him on +2347036740271 

    ReplyDelete

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